Endocrine Abstracts

Hypophagia and increased energy expenditure under inflammatory condition, such as observed after bacterial lipopolysaccharide (LPS) administration, are associated with activation of JAK2–STAT3 signaling in the CNS. High fat diet (HFD) is known to induce hypothalamic resistance to leptin signaling mediated by JAK2–STAT3 pathway. In this study we investigated the expression of p-STAT3 in the hypothalamus and brainstem of HFD treated animals under LPS (100 μg/kg) s...